Some Mb-hypermethylated DMRs become associated with inhibition of binding to CTCF internet
Some Mb-hypermethylated DMRs become associated with inhibition of binding to CTCF internet CCCTC-binding element (CTCF) can become a DNA methylation-sensitive TF and mediate insulation, modulate alternate splicing, and cause alterations in higher-order chromatin build which affect transcription initiation and change topologically related domains (TADs) [ 46 ]. While a features for CpG methylation inside CTCF…
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